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Νίκος Ν. Μαρκομιχελάκης

 

Τόπος γέννησης: Αρχάνες Ηρακλείου Κρήτης

Γυμνασιακές σπουδές: Καπετανάκειο Γυμνάσιο Αρρένων Ηρακλείου

Πανεπιστημιακές  σπουδές: Ιατρική Σχολή Εθνικού και Καποδιστριακού Πανεπιστημίου Αθηνών

Ειδίκευση στην Οφθαλμολογία:  Β’ Οφθαλμολογική Κλινική του Γενικού Κρατικού Νοσοκομείου Αθηνών

Μετεκπαίδευση: Clinical and Research Fellow in Uveitis and Immunology στο Massachusetts Eye and Ear Infirmary της Ιατρικής Σχολής του Πανεπιστημίου Harvard στην Βοστόνη των Η.Π.Α

Διατριβή επί διδακτορία: “Έκφραση κυτταροκινών στους οφθαλμικούς ιστούς μυών με ερπητική αμφιβληστροειδίτιδα” με βαθμό ΑΡΙΣΤΑ.

 

Επαγγελματική σταδιοδρομία

  1. Επιμελητής Β’ στην Οφθαλμολογική Κλινική του Π.Γ.Ν. Αθηνών “Γ.Γεννηματάς” από τον Απρίλιο 1986 μέχρι τον Οκτώβριο 1998 (Διευθυντής: Σταματίνης Χ.) 
  2. Επιμελητής Α’ στην Οφθαλμολογική Κλινική του Π.Γ.Ν. Αθηνών “Γ.Γεννηματάς” από τον Οκτώβριο 1998 μέχρι 2006 (Διευθυντής: Σταματίνης Χ. και Κουρής Τ.)
  3. Αναπληρωτής Διευθυντής στην Οφθαλμολογική Κλινική του Π.Γ.Ν. Αθηνών “Γ.Γεννηματάς” από το 2006 μέχρι το 2009 (Διευθυντής Τ.Κουρής)
  4. Διευθυντής στην Οφθαλμολογική Κλινική του Π.Γ.Ν. Αθηνών “Γ.Γεννηματάς” από το 2009 μέχρι το 2011 (Συντονιστής Διευθυντής Τ.Κουρής)

Υπεύθυνος του Τμήματος φλεγμονών και ανοσολογίας Οφθαλμών του Π.Γ.Ν. Αθηνών “Γ.Γεννηματάς” από το 1995 μέχρι το 2011

Τίτλος: Fellow of the European Board of Ophthalmology το 2002 τιμητικά

 

Δημοσιεύσεις σε διεθνή επιστημονικά Περιοδικά 

  1. “Intravitreal infliximab for sight-threatening relapsing uveitis in Behçet disease: A pilot study in 15 patients
    Markomichelakis ΝΝ, Delicha Ε, MasselosS, Sfikakis PP
    American Journal of Ophthalmology, in press
  2. Structural and functional outcomes after treatment of uveitic macular oedema: an optical coherence tomography and multifocal electroretinogram study” 
    Georgiadou E, Moschos MM, Margetis I, Chalkiadakis J, Markomichelakis NN.
    Clin Exp Optom. 2012 95(1):89-93.
  3. Intravitreal ranibizumab for the treatment of inflammatory choroidal neovascularization
    Rouvas A, Petrou P, Douvali M, Ntouraki A, Vergados I, Georgalas I, Markomichelakis N.
    Retina. 2011;31(5):871-9.
  4. Extensive unilateral visual field loss due to peripapillary arteriovenous malformation.
    Rouvas A, Petrou P, Ladas I, Vergados I, Andipa ES, Papathanasiou M, Markomichelakis N.
    Int Ophthalmol. 2011 Apr;31(2):135-9.
  5. Dexamethasone intravitreal implant for noninfectious intermediate or posterior uveitis
    Ozurdex HURON Study Group 
    Arch Ophthalmol. 2011;129(5):545-53.
  6. A single infliximab infusion vs corticosteroids for acute panuveitis attacks in Behçet's disease: a comparative 4-week study
    Markomichelakis N, Delicha E, Masselos S, Fragiadaki K, Kaklamanis P, Sfikakis PP.
    Rheumatology (Oxford). 2011;50(3):593-7
  7. "Intraocular safari: ophthalmomyiasis interna.
    Georgalas I, Ladas I, Maselos S, Lymperopoulos K, Markomichelakis N.
    Clin Experiment Ophthalmol. 2011;39(1):84-5
  8. Are clusters of patients with distinct clinical expression present in Behçet's disease?
    Arida A, Vaiopoulos G, Markomichelakis N, Kaklamanis P, Sfikakis PP.
    Clin Exp Rheumatol. 2009;27(2 Suppl 53):S48-51.
  9. Retinal angiomatous proliferation (RAP) in a 42-year-old woman with syphilitic retinitis
    Rouvas A, Petrou P, Maselos S, Douvali M, Vergados I, Markomichelakis N.
    Ocul Immunol Inflamm. 2009;17(5):361-3.
  10. Infectious uveitis in children”
    Markomichelakis NN, Chatzistefanou KI, Papaefthymiou I, Koutsandrea C, Kouris T, Apostolopoulos M
    Ophthalmology. 2009 ;116(8):1588, 1588.
  11. Efficacy and safety of latanoprost in eyes with uveitic glaucoma” 
    Markomichelakis NN, Kostakou A, Halkiadakis I, Chalkidou S, Papakonstantinou D, Georgopoulos G.
    Graefes Arch Clin Exp Ophthalmol. 2009;247(6):775-80.
  12. Retinal detachment due to a macular hole in a patient with Behcet disease treated with vitrectomy and silicone oil tamponade” 
    Georgalas I, Markomichelakis N, Ladas I.
    Eur J Ophthalmol. 2008 ;18(6):1023-4.
  13. Tumor necrosis factor inhibitors and uveitis: comment on the article by Lim et al” 
    Sfikakis PP, Markomichelakis N.
    Arthritis Rheum. 2008;58(5):1554-5; author reply
  14. Spinocerebellar ataxia type 7 presenting as Stargardt's disease” 
    Tsivgoulis G, Vassilopoulou S, Rallis K, Markomichelakis N, Spengos K. 
    J Neurol. 2008;255(3):456-8.
  15. Course of macular edema in uveitis under medical treatment.
    Markomichelakis NN, Halkiadakis I, Pantelia E, Georgalas E, Koutsandrea C, Theodossiadis P, Moschos M, Theodossiadis G, Kouvatseas G. Ocul Immunol Inflamm. 2007;15(2):71-9.
  16. Anti-TNF therapy in the management of Behcet's disease--review and basis for recommendations.
    Sfikakis PP, Markomichelakis N, Alpsoy E, Assaad-Khalil S, Bodaghi B, Gul     A, Ohno S, Pipitone N, Schirmer M, Stanford M, Wechsler B, Zouboulis C, Kaklamanis P, Yazici H.
    Rheumatology (Oxford). 2007;46(5):736-41.
  17. Tumor necrosis factor antagonists: preliminary evidence for an emerging approach in the treatment of ocular inflammation.
    Theodossiadis PG, Markomichelakis NN, Sfikakis PP.
    Retina. 2007;27(4):399-413.
  18. “Acanthamoeba keratitis and contact lens disifecting solutions”
    Tzaneto K, Miltsakakis D, Droutsas D, Alimisi S, Petropoulou D, Ganteris G, Dolapsaki E, Markomichelakis N, Mallias I, Malamou-Lada E.
    Ophthalmologica 2006;220:238-41
  19. “Pressure wave reflections, central blood pressure, and aortic stiffness in patients with adamantiades-Behcet’s diasease”
    Protogerou AD, Lekakis J, Ikonomidis I, Stamatelopoulos K, Aznaouridis K, Karatzis EN, Papamichael C, Markomichelakis N, Kaklamanis P, Mavrikakis M 
    American Jurnal of Hypertension 2006;19:660-6
  20. “Intravenous pulse methylprednisolone therapy for acute treatment of  serpiginous choroiditis” 
    Markomichelakis ΝΝ, Halkiadakis Ι,Papaeythymiou-Orchan S,Giannakopoulos N, Ekonomopoulos N, Kouris T
    Ocular Immunolgy and Infflammation 2006;14(1):29-33.
  21. Spinal muscular atrophy, Dandy-Walker complex, and cataracts in two siblings: a new entity?
    Panas M, Spengos K, Tsivgoulis G, Kalfakis N, Sfagos C, Vassilopoulos D, Markomichelakis N.
    J Neurol Neurosurg Psychiatry. 2005 Aug;76(8):1183-4.
  22. “Regression of neovascular age-related macular degeneration following infliximab therapy.” 
    Markomichelakis NN, Theodossiadis PG, Sfikakis PP.
    American Journal of Ophthalmology. 2005;139(3):537-40.
  23. «Regression of sight-threatening macular edema in type 2 diabetes following treatment with the anti-tumor necrosis factor monoclonal antibody infliximab»
    Sfikakis PP, Markomichelakis NN, Theodossiadis GP, Grigoropoulos V, Katsilambros N Theodossiadis PG  
    Diabetes Care 2005;28: 445-7
  24. “Prognostic factors in Intermediate uveitis”
    Markomichelakis N,Chatzistefanou K,Dafni U,Christen W,Rojas B,Sohelian M,Foster S 
    Middle East Journal of Ophthalmology 2004;12: 155-61
  25. “Characteristics of systemic disease-associated and idiopathic pars planitis”
    Markomichelakis NN,Chatzistefanou K,Dafni U,Christen W,Zafirakis P,Rojas B,Foster S 
    Middle East Journal of Ophthalmology 2004;12:5-12
  26. Infliximab for chronic cystoid macular edema associated with uveitis”
    Markomichelakis N, Theodossiadis P, Pantelia E. Theodossiadis G, Sfikakis P.
    American Journal of Ophthalmology 2004;138:648-650 .
  27. “Patterns of macular edema in patients with uveitis: qualitative and quantitative assessment using optical coherence tomography.” 
    Markomichelakis NN, Halkiadakis I, Pantelia E, Peponis V, Patelis A, Theodossiadis P, Theodossiadis G.
    Ophthalmology. 2004 May;111:946-53
  28.  “Aortic elastic properties and left ventricular diastolic function in patinents with Adanatiades-Behcet’s disease”   
    Ikonomidis I, Lekakis J, Stamatelopoulos K, Markomichelakis N, Kaklamanis Ph, Mavrikakis M.
    Journal of the American College of Cardiology Foundation, 2004;43:1075-81  
  29. “Onset signs, clinical course, prognosis, treatment and outcome of adult patients with Adamantiades-Behcet’s disease in Greece”
    Zouboulis CC, Vaiopoulos G, Markomichelakis N, Palimeris G, Markidou I, Thouas B, Kaklamanis P.
    Clinical and Experimenatl Rheumatology 2003; 21 (Suppl. 30); S19-S26
  30. “Arterial wall characteristics in patients with Adamantiades-Behcet's disease”
    Protogerou A, Lekakis J, Stamatelopoulos K, Aznaouridis K, Karatzis E, Ikonomidis I, Papamichael Ch, Markomihelakis N, Mavrikakis M, Kaklamanis PG.
    Advanced Experimental Medicin and Biology. 2003;528:399-404
  31. “Human mast cell subtypes in conjunctiva of patients with atopic keratoconjunctivitis, ocular cicatricial pemphigoid and Stevens-Johnson syndrome.”
    Yao L, Baltatzis S, Zafirakis P, Livir-Rallatos C, Voudouri A, Markomichelakis N, Zhao T, Foster S.
    Ocular Immunology and Inflammation 2003;11:211-22. 
  32. “The effect of smoking on the clinical features of Adamantiades-Behcet's disease”
    Kaklamani VG, Tzonou A, Markomichelakis N, Papazoglou S, Kaklamanis PG.
    Advanced Experimental Medicin and Biology 2003;528:323-7.
  33. “Macular hole closure after peribulbar steroid injection”
    Halkiadakis I,Pantelia E,Giannakopoulos N,Koutsandrea C,Markomichelakis N.
    American Journal of Ophthalmology. 2003;136:1165-7
  34. “Infliximab for recurrent, sight-threatening ocular inflammation in Adamantiades-Behcet’s disease” 
    Sfikakis PP, Kaklamanis PH, Elezoglou A, Katsilambros N, Theodossiadis PG, Papaefthimiou S, Markomichelakis N.
    Annales of Internal Medicine. 2004;140:404-6
  35. "Successful long-term treatment of refractory Adamantiades-Behcet's disease (ABD) with infliximab: report of two patients”
    Katsiari G, Theodossiadis PG, Kaklamanis PG, Markomichelakis N, Sfikakis P.
    Advanced Experimental Medicin and Biology 2003;528:551-5.
  36. “Could Nicotine be beneficial for Behcet’s disease”
    Kaklamani VG, Markomichelakis N, Kaklamanis Ph
    Clinical Rheumatology (let) 2002;21:341-342
  37. “Cytomegaloviruys can cause Anterior Uveitis with Sectoral Iris Atrophy”
    Markomichelakis N, Canakis Ch, Zafirakis P, Marakis Th, Mallias I, Theodossiadis G. 
    Ophthalmology 2202;109:879-882    
  38. “Effect of Infliximab on side-threatening panuveitis in Behcet’s disease”
    Sfikakis P, Thedossiadis P, Katsiari C, Kaklamanis Ph, Markomichelakis
    Lancet 2001;358(9278):295-6. 
  39. “Herpes simplex virus type 2: a cause of acute retinal necrosis syndrome”  
    Markomichelakis N, Zafirakis P,Karampoyia P,Drakoulis N,Apostolopoulos M.
    Ocular Immunology and Inflammation 2001;9(2):103-9.
  40. “Evaluation of the hydrogel foldable intraocular lens in patients with uveitis”
    Baltatzis S, Zafirakis P, Voudouri A, Livir-Ralatos G, Livir-Ralatos C, Kanakis C, Mitsionis,Markomichelakis N.
    Investigative Ophthalmology & Visual Science 2001;42:S5 
  41. “Immunopathology of ocular rosacea”
    Zafirakis P, Baltatzis S, Voudouri A, Livir-Ralatos G, Livir-Ralatos C, Markomichelakis N, Foster CS.     
    Investigative Ophthalmology & Visual Science 2001;42:S577 
  42. “Standard Versus separate Phacotrabeculectomy: A randomized study”
    Voudouri A, Zafirakis P, Livir-Ralatos G, Markomichelakis N, Mitsionis I, Baltatzis S,
    Investigative Ophthalmology & Visual Science 2001;42:S822 
  43. “High levels of Tumor Necrosis Factor –a (TNF-a) in the aqueous humor in patients suffering from Adamandiades-Behcet disease: Preliminary results”
    Chronopoulou H, Tzavara N, Ekonomopoulos N, Zafirakis P, Theodosiadis P, Tzioufas T, Markomichelakis N.
    Investigative Ophthalmology & Visual Science 2001;42:S708
  44. "Recurrent epididymo-orchitis in patients with Behcet’s disease”
    Kaklamani VG, Vaiopoulos G, Markomichelakis N, Kaklamanis Ph.
    Journal of Urology 2000; 163:487-9     
  45. “Human leukocyte antigens (HLA) and intermediate uveitis”
    Markomichelakis N, Zafirakis P, Chatzistefanou C, Kokolakis S, Theodosiadis G.
    Ocular Immunology and Inflammation 2000; 8:210  
  46. “Costimulatory molecules in conjunctiva from patients with Stevens Johnson syndrome”
    Zafirakis P, Dorfman DM, Baltatzis S, Voudouri A, Livir-Rallatos, Markomichelakis N, Foster CS 
    Investigative Ophthalmology & Visual Science 2000;41:S672  
  47. “ Combined cyclpsporine-A, corticosteroid and azathioprine treatment for uveitis in Adamantiades-Behcet disease. Preliminary results”
    Markomichelakis N, Zafirakis P, Canakis C, Tziufas A, Manousakis E, Mallias I, Theodosiaidis G.
    Investigative Ophthalmology & Visual Science 2000;41:S370 
  48.  “Clinical features of Adamandiades-Behcet disease in Greece”
    Kaklamani V, Markomichelakis N, Vaiopoulos G, Papazoglou S, Kaklamanis P.
    Yonsei Medical Journal 2000;41(Suppl):10   
  49. “Clinical features of juvenile Adamantiades-Behcet’s disease in Greece”
    Vaiopoulos G,Kaklamani V,Markomichelakis N,Tzonou M,Mavrikakis M,Kaklamanis P.
    Clinical and Experimental Rheumatology 1999;17:256-9  
  50. “Retinal vasculitis with a frosted branch angiitis-like response due to herpes simplex virus type 2”
    Markomichelakis N, Barampouti F, Zafirakis P, Chalkiadakis I, Kouris T, Ekonomopoulos N
    Retina 1999;19:455-7    
  51. “CME in a patient with AIDS and past ocular history of CMV retinitis after initiation of protease inhibitors”
    Zafirakis P, Markomichelakis N, Venturi M, Theodosiadis P, Theodosiadis G.
    Documenta Ophthalmologica, 1999;97:311-315   
  52. “Medical treatment of macular edema in patients with uveitis”   
    Rojas B, Zafirakis P, Christen W, Markomichelakis N, Foster CS.     
    Documenta Ophthalmologica, 1999;97:399-407
  53. "Immunopathology of Mooren’s ulcer”
    Zafirakis P, Baltatzis S, Livir-Ralatos C, Voudouri A, Markomichelakis N, Foster CF.
    Investigative Ophthalmology & Visual Science 1999;40:S559 
  54. 'Human mast cell subsets in conjunctiva from patients with atopy and ocular cicatricial pemphigoid’
    Baltatzis S, Zafirakis P, Livir-Ralatos C, Voudouri A, Markomichelakis N, Foster CF. 
    Investigative Ophthalmology & Visual Science 1999;40:S558   
  55. “HLA-B* 5101 in greek patients with Behcet’s disease”
    Koumaniaki I, Stavropoulos C, Spyropoulou M, Messini H, Papademitropoulos M, Giziaki E, Markomichelakis N, Palimeris G, Kaklamanis PH, Kaklamani E.
    Human Immunology 1998;59:250-5 
  56. “Characteristics of uveitis presenting for the first time in the elderly”
    Chatzistefanou Κ, Markomichelakis Ν, Christen W, Soheilian M,  Foster CS.
     Ophthalmology 1998;105:347-52 
  57. “Retinopathy and optic neuropathy after transplantation”
    Theodosiadis P, Vergados I, Markomichelakis N, Ladas I, Skandali A. (let)
    Ophthalmology 1997;104:170-171 
  58. “Retinal perivasculitis in an immunocompetent patient with systemic herpes siplex virus”
    Chatzoulis D, Theodosiadis P, Apostolopoulos M, Drakoulis N Markomichelakis N.
    American Journal of Ophthalmology, 1997;123:699-702  
  59. “DNA techniques in the diagnosis and the monitoring of treatment for systemic HSV infection of an immunocompetent patient with retinal perivasculitis”
    Haliassos A, Markomichelakis N, Drakoulis N.
    European Journal of Clinical Pharmacology 1997; 52 (Suppl):A181, 587   
  60. “Intermediate uveitis and vasculitis: new ocular manifestations in cat scratch disease”
    Soheilian M, Markomichelakis N, Foster CS.
    American Journal of Ophthalmology, 1996;122:582-584
  61. “Medical treatment of cystoid macular edema in patients with uveitis”
    Rojas B, Christen B, Markomichelakis N, Foster CS.
    Investigative Ophthalmology & Visual Science 1996;36:S340    
  62. "Intermediate uveitis. What is the natural course of the disease and its relationship with other systemic diseases?”
    Palimeris G, Markomichelakis N, Konstantinidou V, Trakaniari AN.
    European Journal of Ophthalmology 1994;3:223-27
  63. “Detection of HSV, CMV, and EBV by the polymerase chain reaction technique in patients with inflammatory eye diseases”    
    Ergazaki M,Xinarianos G,Giannoudis A,Markomichelakis N, Tsamparlakis I, Spandidos D. 
    D Oncology Reports 1994;1:1207-13
  64. “ND:YAG LASER coreoplasty in a patient with ocular leprosy”
    Ladas I, Markomichelakis N, Makrinori F. In: Recent Advances in Uveitis.
    Dernouchamps J, Verougstraete C, Caspers-Velou L, Tassignon MJ (edts).
    Kugler Publication, Amstredam 1993: 623-627                                                
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